Special Issue on HOX Genes in Development
نویسنده
چکیده
This Special Issue of Journal of Developmental Biology (JDB) covers an indeed very "special" (at least to me) family of highly evolutionarily conserved genes, the Hox genes.[...].
منابع مشابه
Hox and ParaHox Genes in Evolution, Development and Genomics
The discovery of the homeobox motif and its presence in each gene of the Hox clusters revolutionized the fields of developmental biology and evolutionary developmental biology (1, 2), providing a rapid entrance into investigating the mechanisms of development of almost any animal taxon as well as dramatically altering conceptions on the extent of genetic conservation across the animal kingdom. ...
متن کاملMoD Special issue on “Upstream and Downstream of Hox Genes
The antero-posterior axis of bilaterian is determined by set of homeodomain transcription factors encoded by the hox genes that are organized into gene clusters. Remarkably, the arrangement of the hox genes along the chromosome within the cluster corresponds to the order of the structures that are specified along the antero-posterior body axis of the organism. This conserved organization is tho...
متن کاملO-28: Role of HOX Family Related Genes in Pain Generation of Endometriosis Patients
Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...
متن کاملVertebrate hox gene regulation: clustering and/or colinearity?
The relationship between the clustered organization of vertebrate Hox genes and their coordinate transcription in space and time is still lacking a convincing mechanistic explanation. Recent work on the regulatory interactions within Hox complexes suggests some reasons why these genes have remained clustered. Although these results do not address the puzzling issue of colinearity directly, they...
متن کاملShaping segments: Hox gene function in the genomic age.
Despite decades of research, morphogenesis along the various body axes remains one of the major mysteries in developmental biology. A milestone in the field was the realisation that a set of closely related regulators, called Hox genes, specifies the identity of body segments along the anterior-posterior (AP) axis in most animals. Hox genes have been highly conserved throughout metazoan evoluti...
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2017